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FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 896-908 doi: 10.1007/s11684-022-0944-z

Abstract: Fibroblast growth factor 13 (FGF13) is aberrantly expressed in multiple cancer types, suggesting itsResults showed that FGF13 was lowly expressed in patients with AML and that its elevated expression wasUnivariate and multivariate Cox regression analyses identified FGF13 as an independent prognostic factorA prognostic nomogram integrating FGF13 and clinicopathologic variables was constructed to predict 1-The xenograft study indicated that FGF13 overexpression prolonged the survival of recipient mice.

Keywords： acute myeloid leukemia     FGF13     prognosis     immune-related genes     bone marrow niches    

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The FGF metabolic axis

Xiaokun Li

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 511-530 doi: 10.1007/s11684-019-0711-y

Abstract: Members of the fibroblast growth factor (FGF) family play pleiotropic roles in cellular and metabolicDuring evolution, the ancestor FGF expands into multiple members by acquiring divergent structural elementsBy contrast, FGF19, 21, and 23 coevolve through losing binding affinity for extracellular matrix heparanFGF19 metabolic axis from the ileum to liver negatively controls diurnal bile acid biosynthesis.The significant divergence in structural elements and multiple functional specifications of FGF19, 21

Keywords： FGF19     FGF21     FGF23     FGFR     metabolism     endocrine     Klotho    

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FGF23 associated bone diseases

Eryuan Liao

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 65-80 doi: 10.1007/s11684-013-0254-6

Abstract:

Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potentialIn this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin Dmetabolism, and the FGF23 related bone disease.

Keywords： fibroblast growth factor 23     FGF receptor     phosphate metabolism     Klotho     bone disease    

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Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 61-66 doi: 10.1007/s11684-009-0007-8

Abstract: The expression of Shh and Fgf8 at mRNA and protein levels in neonatal rat myocardial cells were measuredThere was basal expression of Shh and Fgf8 in the control group.Meanwhile, we could detect that the expression of Fgf8 mRNA and protein were up-regulated by 2.50 timesThe results indicated that RA could induce the expression of Shh and Fgf8 in neonatal rat myocardialAt the same time, it has shown that Shh and Fgf8 were involved in the regulation process of RA on TBX1

Keywords： retinoic acid     Tbx1 protein     Shh protein     Fgf8 protein    

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RESPONSE OF WHEAT COMPOSITE CROSS POPULATIONS TO DISEASE AND CLIMATE VARIATION OVER 13 GENERATIONS

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 3,   Pages 400-415 doi: 10.15302/J-FASE-2021394

Abstract:

Since the F5 (2005), three winter wheat composite cross populations (CCPs) based on germplasm specifically suitable for low-input conditions were subjected to natural selection under organic and conventional management. In the F6, each CCP was divided into two parallel populations (12 CCPs in total) and maintained continuously until 2018. Commonly used modern cultivars with different disease susceptibilities were grown alongside to assess the agronomic performance of the CCPs. The organically managed CCPs were comparable in yield and foliar disease resistance to two continuously used reference cultivars, Achat and Capo. In contrast, under conventional management the cv. Capo outyielded the CCPs (Achat was not tested), highlighting the importance of parental cultivar choice for specific management systems. The CCPs were found to be moderately resistant to brown rust and even to the newly emerged stripe rust races prevalent in Europe since 2011. Differences between the CCPs were mainly due to parental genetic background and were significant in the first five generations, but were no longer so in the last five generations. In addition, these differences tended to vary depending on the experimental year and the environmental stresses present. In conclusion, the CCPs despite being derived from older cultivars are able to compete with more recently released reference cultivars under organic farming practices and represent a dynamic germplasm resource.

 

Keywords： evolutionary breeding     heterogeneous crop population     management system    

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Human health ambient water quality criteria for 13 heavy metals and health risk assessment in Taihu Lake

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 4, doi: 10.1007/s11783-021-1475-6

Abstract:

• The concentrations of 13 heavy metals in Taihu Lake were analyzed.

Keywords： Heavy metals     Human health ambient water quality criteria     Taihu Lake     Health risk assessment     Contribution rate    

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 25-30 doi: 10.1007/s11684-013-0244-8

Abstract:

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family.It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolismMoreover, FGF21 also plays important roles in some physiological processes, such as fasting and feedingClinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21This article concentrates on recent advances in our understanding of FGF21.

Keywords： FGF21     metabolism     pharmacology     physiology     clinical relevance    

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Low-temperature CO oxidation over Au-doped 13X-type zeolite catalysts: preparation and catalytic activity

Qing YE, Donghui LI, Jun ZHAO, Jiansheng ZHAO, Tianfang KANG, Shuiyuan CHENG

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 4,   Pages 497-504 doi: 10.1007/s11783-011-0256-z

Abstract: Au-supported 13X-type zeolite (Au/13X) was synthesized using a common deposition–precipitation (DP) methodchloroauric acid concentration, solution temperature, pH of solution, and calcinations temperature) on Au/13Xcatalytic activity, the relationship between different the preparation conditions and gold particles in 13XThe activity of Au/13X catalysts in CO oxidation was dependent on the chloroauric acid concentration.Furthermore, a pH of 5 or 6 generated greater amounts of Au loading and smaller Au particles on 13X than

Keywords： 13X-type zeolite     CO oxidation     gold solution     pH     calcination temperature    

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Prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13–14 years in Northeast Iran

Fatemeh Mehravar,Soheil Rafiee,Behnaz Bazrafshan,Mahmoud Khodadost

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 345-350 doi: 10.1007/s11684-016-0462-y

Abstract: study aimed to examine the prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13&The prevalence rate was compared according to age group (aged 6–7 years vs. aged 13–14 yearsIn this cross-sectional study, 1706 Iranian schoolchildren aged 6–7 and 13–14 years in Golestanasthma ever” and “wheezing in the past 12 months”) in junior high schoolchildren (aged 13&that in girls in both age groups, and the severity of asthma in girls is higher than that in boys aged 13&

Keywords： asthma     asthma symptoms     epidemiology     childhood     chronic disease    

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Separating method and dynamic processes of Nano-Al13

GAO Baoyu, YUE Qinyan, WANG Xiaona, CHU Yongbao, KONG Chunyan

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 3,   Pages 368-373 doi: 10.1007/s11783-007-0063-8

Abstract: In order to investigate the characteristics of pure Nano-Al, Nano-Al was separated and purified from a series of poly-aluminum chloride (PAC) solutions which had the same Al percentage but different total Al concentrations, by using column chromatography, ethanol-acetone resolving and SO/Ba displacement. The Al species yield was characterized by Al-ferron timed complexation spectrophotometry and Al-NMR (nuclear magnetic resonance). The coagulation efficiency of Nano-Al, PAC and AlCl in synthetic water was also investigated by Jar tests. The dynamic process and aggregation state of kaolin suspensions coagulating with Nano-Al, PAC and AlCl were similarly investigated using a photometric dispersion analyzer 2000 (PDA2000). The experimental results indicated that the ethanol-acetone resolving method was simple and could separate the PAC solution at different concentrations, while column chromatography could separate PAC solutions at low concentrations. The SO/Ba displacement method could separate PAC solutions at high concentrations. However, extra inorganic cation and anion could be added in the solution during separation. The coagulation efficiency and dynamic experimental results showed that Nano-Al with high positive-charged species was effective in removing turbidity and color. The dynamic process results showed that Nano-Al also had the best recovery capability after shearing compared with PAC and AlCl because the Nano-Al conformation is more effective in charge neutralization.

Keywords： displacement     PAC     coagulation efficiency     poly-aluminum     inorganic    

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A novel method for reconstruction in laparoscopic pancreaticoduodenectomy: an experience of 13 cases

LU Bangyu, HUANG Yubin, CAI Xiaoyong, HUANG Fei, LU Wenqi, XU Jing, LIU Zujun, YAN Yihe, LI Jianjun, LI Jie

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 369-372 doi: 10.1007/s11684-007-0071-x

Abstract: We analyze 13 cases of LPD performed in our center.

Keywords： alimentary     dunking pancreaticojejunostomy     challenging operation     anastomosis     success    

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Analysis and Policy Suggestions on Development of Chinese Husbandry Industry during the Period of the 13th

Research Group of Strategic Planning of Chinese Husbandry Development for the 13th Five-Year Plan

Strategic Study of CAE 2016, Volume 18, Issue 1,   Pages 17-21 doi: 10.15302/J-SSCAE-2016.01.003

Abstract:

During the period of the 13th Five-Year Plan and even in a long period in the future, the demand forAiming at the 13th Five-Year Plan, the paper develops the strategic objectives, strategic priorities

Keywords： huasbandry industry     sustainable development     the 13th Five-Year Plan     trend analysis     food safety    

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Study on the Goals and Key Tasks of Eco-Civilization Construction in the 13th Five-Year Plan Period

Shu Jianmin,Zhang Linbo,Luo Shanghua,Du Jiaqiang and Liang Guanglin

Strategic Study of CAE 2015, Volume 17, Issue 8,   Pages 39-45

Abstract:

The 13th Five-Year Plan period is crucial for China to accelerate eco-civilizationeco-civilization construction, this paper proposes the goal and obligatory targets of eco-civilization in the 13th

Keywords： eco-civilization construction     13th Five-Year Plan period     key tasks     policy recommendations    

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Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 104-111 doi: 10.1007/s11684-017-0568-x

Abstract: Mitochondrion-localized retinol dehydrogenase 13 (Rdh13) is a short-chain dehydrogenase/reductase involvedWe previously generated knockout mice and showed that Rdh13 deficiency causes severe acute retinaleffect of Rdh13 on liver injury induced by carbon tetrachloride (CCl ).Although Rdh13 deficiency showed no significant effect on liver histology and physiological functionsFurthermore, the mice had Rdh13 deficiency and thus their liver cells were protected from apoptosis

Keywords： retinol dehydrogenase 13     carbon tetrachloride     acute liver injury     Cyp2e1     Spot14    

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ARC-13-009716-01) A preliminary version was presented at the 13th International

Maiquel DE BRITO,Lauren THÉVIN,Catherine GARBAY,Olivier BOISSIER,Jomi Fred HÜBNER

Frontiers of Information Technology & Electronic Engineering 2016, Volume 17, Issue 4,   Pages 309-324 doi: 10.1631/FITEE.1500369

Abstract: This paper highlights the use of situated artificial institution (SAI) within a hybrid, interactive,normative multi-agent system to regulate human collaboration in crisis management. Norms regulate the actions of human actors based on the dynamics of the environment in which they are situated. This dynamics results from both environment evolution and actors’ actions. Our objective is to situate norms in the environment in order to provide a context-aware crisis regulation. However, this coupling must be a loose one to keep both levels independent and easyto-change in order to face the complex and changing crisis situations. To that aim, we introduce a constitutive level between environmental and normative states providing a loose coupling of normative regulation with environment evolution. Norms are thus no more referring to environmental facts but to status functions, i.e., the institutional interpretation of environmental facts through constitutive rules. We present how this declarative and distinct SAI modelling succeeds in managing the crisis with a context-aware crisis regulation.

Keywords： Situated artificial institutions (SAIs)     Normative system     Tangible interaction     Crisis management    

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Title Author Date Type Operation

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Journal Article

The FGF metabolic axis

Xiaokun Li

Journal Article

FGF23 associated bone diseases

Eryuan Liao

Journal Article

Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

Miao LIU, Xiaoyan WU, Jiawei XU, Runming JIN

Journal Article

RESPONSE OF WHEAT COMPOSITE CROSS POPULATIONS TO DISEASE AND CLIMATE VARIATION OVER 13 GENERATIONS

Journal Article

Human health ambient water quality criteria for 13 heavy metals and health risk assessment in Taihu Lake

Journal Article

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Journal Article

Low-temperature CO oxidation over Au-doped 13X-type zeolite catalysts: preparation and catalytic activity

Qing YE, Donghui LI, Jun ZHAO, Jiansheng ZHAO, Tianfang KANG, Shuiyuan CHENG

Journal Article

Prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13–14 years in Northeast Iran

Fatemeh Mehravar,Soheil Rafiee,Behnaz Bazrafshan,Mahmoud Khodadost

Journal Article

Separating method and dynamic processes of Nano-Al13

GAO Baoyu, YUE Qinyan, WANG Xiaona, CHU Yongbao, KONG Chunyan

Journal Article

A novel method for reconstruction in laparoscopic pancreaticoduodenectomy: an experience of 13 cases

LU Bangyu, HUANG Yubin, CAI Xiaoyong, HUANG Fei, LU Wenqi, XU Jing, LIU Zujun, YAN Yihe, LI Jianjun, LI Jie

Journal Article

Analysis and Policy Suggestions on Development of Chinese Husbandry Industry during the Period of the 13th

Research Group of Strategic Planning of Chinese Husbandry Development for the 13th Five-Year Plan

Journal Article

Study on the Goals and Key Tasks of Eco-Civilization Construction in the 13th Five-Year Plan Period

Shu Jianmin,Zhang Linbo,Luo Shanghua,Du Jiaqiang and Liang Guanglin

Journal Article

Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

Journal Article

ARC-13-009716-01) A preliminary version was presented at the 13th International

Maiquel DE BRITO,Lauren THÉVIN,Catherine GARBAY,Olivier BOISSIER,Jomi Fred HÜBNER

Journal Article